HK2

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Hexokinase 2 (HK2) is a protein present in humans. It is primarily produced in the prostate, and is regulated by androgens through the androgen receptor.[1] It is closely related to PSA, sharing about 80% of its genetic sequence.[2] Like PSA, it is sometimes used as a biomarker for prostate cancer.[2]

Response to antiandrogens[edit]

Cyproterone acetate (with and without estrogens)[edit]

Trans women aged 18-50 years (median 30 years) treated with 100 mg/day cyproterone acetate had the following HK2 response:[1]

Median plasma HK2 Mean plasma HK2 Median urine HK2
Baseline 4 months 12 months Baseline 4 months 12 months Baseline 4 months 12 months
Treatment Subjects ng/L ng/L change ng/L change ng/L ng/L change ng/L change ng/L ng/L change ng/L change
100 mg/day CPA 10 216 28 -87% - - - - - - - 1258 104 -92% - -
100 mg/day CPA and
17β-estradiol patch twice weekly
15 201 16 -92% - - - - - - - 1016 39 -96% - -
100 mg/day CPA and
100 ug/day oral ethinylestradiol
31 193 6.3 -97% 9.0a -95%a 208 14 -93% 16 -92% 1180 43 -96% 46a -96%a

a Only 17 of the original 31 subjects were analyzed at the 12 month mark.

References[edit]

  1. 1.0 1.1 Christina V. Obiezu et al (2000). "DRAMATIC SUPPRESSION OF PLASMA AND URINARY PROSTATE SPECIFIC ANTIGEN AND HUMAN GLANDULAR KALLIKREIN BY ANTIANDROGENS IN MALE-TO-FEMALE TRANSSEXUALS". The Journal of Urology. 163 (3): 802–805. doi:10.1016/S0022-5347(05)67808-1. ISSN 00225347.
  2. 2.0 2.1 K. Clint Cary et al (2013). "Biomarkers in prostate cancer surveillance and screening: past, present, and future". Therapeutic Advances in Urology. 5 (6): 318–329. doi:10.1177/1756287213495915. PMC 3825107. PMID 24294290. ISSN 1756-2872.