HK2

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Hexokinase 2 (HK2) is a protein present in humans. It is primarily produced in the prostate, and is regulated by androgens through the androgen receptor.[1] It is closely related to PSA, sharing about 80% of its genetic sequence.[2] Like PSA, it is sometimes used as a biomarker for prostate cancer.[2]

Response to antiandrogens

Cyproterone acetate (with and without estrogens)

Trans women aged 18-50 years (median 30 years) treated with 100 mg/day cyproterone acetate had the following HK2 response:[1]

Median plasma HK2 Mean plasma HK2 Median urine HK2
Baseline 4 months 12 months Baseline 4 months 12 months Baseline 4 months 12 months
Treatment Subjects ng/L ng/L change ng/L change ng/L ng/L change ng/L change ng/L ng/L change ng/L change
100 mg/day CPA 10 216 28 -87% - - - - - - - 1258 104 -92% - -
100 mg/day CPA and
17β-estradiol patch twice weekly
15 201 16 -92% - - - - - - - 1016 39 -96% - -
100 mg/day CPA and
100 ug/day oral ethinylestradiol
31 193 6.3 -97% 9.0a -95%a 208 14 -93% 16 -92% 1180 43 -96% 46a -96%a

a Only 17 of the original 31 subjects were analyzed at the 12 month mark.

References

  1. 1.0 1.1 Christina V. Obiezu et al (2000). "DRAMATIC SUPPRESSION OF PLASMA AND URINARY PROSTATE SPECIFIC ANTIGEN AND HUMAN GLANDULAR KALLIKREIN BY ANTIANDROGENS IN MALE-TO-FEMALE TRANSSEXUALS". The Journal of Urology. 163 (3): 802–805. doi:10.1016/S0022-5347(05)67808-1. ISSN 00225347.
  2. 2.0 2.1 K. Clint Cary et al (2013). "Biomarkers in prostate cancer surveillance and screening: past, present, and future". Therapeutic Advances in Urology. 5 (6): 318–329. doi:10.1177/1756287213495915. PMC 3825107. PMID 24294290. ISSN 1756-2872.