Dihydrotestosterone

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Dihydrotestosterone
Androstanolone.svg
Drug class: Endogenous androgen
Dosage range: : -
 : -
Brand names: Anabolex; Andractim; AndroGel-DHT; Androlone; Stanolone


Dihydrotestosterone (DHT) is an androgen that is made by converting testosterone into DHT via 5α reductase (5αr).

It is responsible for multiple androgenic physical effects during puberty, and 5αr is also associated with several bodily functions, such as regulating circadian rhythms. [citation needed]

There are 3 isoforms of DHT which are located in different tissues of the body:

  • Type 1: present in most tissues
  • Type 2: present in genital tissues (non skin) and hair. Found in the prostate, and liver.
  • Type 3: Wide tissue distribution, including the brain, skin, ovary, small intestine, and kidney. [1][2]

DHT inhibitors

DHT is responsible for physical effects such as acne, bottom growth, and hair loss.[citation needed] When these effects are an undesirable element of transition (or leftover effects from first puberty) you may want to use pharmaceutical or natural methods to lower your DHT.

If you want more information about reducing erections or bottom growth, visit the article on nitric oxide synthase (NOS) or see our experimental regimen for limiting bottom growth. Certain authors of this wiki speculate that NO reduction combined with DHT reduction could be a potent inhibitor of bottom growth.

Pharmaceutical 5ar inhibitors on the market include finasteride and dutasteride.[citation needed]

Natural 5αr/DHT inhibitors include:

  • Green tea.[3] Epigallocatechin gallate (EGCG) is found in black and green tea, and the most in green tea. EGCG downregulates DHT and T by reducing the transcription of androgen receptors. Matcha tea has a much higher EGCG content. [4][5] Green tea is also a nonsteriodal inhibitor of 5-α reductase.
  • Cruciferous vegetables contain indole-3-carbinol, which inhibits and downregulates 5αr, at least in cancerous prostate cells. [6]
  • Aromatase production (more E) combined with a 5α reductase inhibitor downregulates 5αr in the corpora cavernosum[citation needed], which is responsible for penile erections.
  • Flax seed [7]
  • Fenugreek [8]
  • Curcumin [9][10]
  • Saw palmetto [11][12]
  • Black pepper [13]
  • Pumpkin seed oil [14]
  • Nettle root [citation needed]
  • Red reishi [15]
  • Nettle root [16]
  • Cinnamon [17]

References